|Man Without Qualities
Tuesday, June 28, 2005
Responding to the earlier post And The Number One Cancer Myth Is ... , an astute reader e-mails:
[O]ne proposed mechanism for the “paradoxical” finding of accelerated post-surgery metastasis is the release of angiostatic signals by the primary tumor. It’s no surprise that Folkman would be involved in this area, but you may be interested to learn that one Gianni Bonadonna, one of the great innovators of chemotherapy treatment, has also long endorsed this hypothesis. A recent paper (coauthored with Folkman) is cited below.
Hypothesis: Induced angiogenesis after surgery in premenopausal node-positive breast cancer patients is a major underlying reason why adjuvant chemotherapy works particularly well for those patients.
Retsky M, Bonadonna G, Demicheli R, Folkman J, Hrushesky W, Valagussa P.
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