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It's pretty well known that large doses of certain drugs such as aspirin can damage the inner ear and result in tinnitus (ringing ears).
But the connection between some pain killing drugs and hearing loss seems to go much further:
Doctors over the past several years have reported dozens of cases of Vicodin addicts who became deaf and, in some cases, only regained their hearing with the help of cochlear implants such as the ones received by [Rush] Limbaugh. ...
When he initially lost his hearing, experts suspected Limbaugh suffered from autoimmune disorder... But last week, another potential cause revealed itself when Limbaugh announced he was addicted to painkillers -- reportedly including Vicodin (also known as hydrocodone).